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Description Essentiale 250 mg / 5 ml amp. 5 ml:
The active ingredient in the so-called essential phospholipids (EPL-substance), which are highly purified fraction of phosphatidylcholine. The defining component of this fraction is дилинолеоилфосфатидилхолин. Essential phospholipids on their chemical structure similar to endogenous membrane phospholipids, exceeding them by their functional properties due to the high content of polyunsaturated fatty acids, especially linoleic acid. Phospholipids are the basic building blocks of cell membranes and organel. They are involved in differentiation, division and cell regeneration.
Functional significance of phospholipids based on their amphiphilic properties, which allow you to adjust the permeability of cell membranes. They improve the function of membranes, in particular ion exchange, the process of intracellular respiration and biological oxidation, affect the binding of intracellular respiratory enzymes in mitochondria, as well as on the process of oxidative phosphorylation to energy metabolism of cells. Under physiological conditions, the synthesis of phospholipids meet the normal requirements of hepatocytes, which contain a sufficient amount of phospholipids. It is known that the structure of cell membranes and function of enzyme systems in liver diseases are violated. Disrupted the biosynthesis of phospholipids, the shortage of which leads to dysfunction of the cell membrane. These processes are especially pronounced in mitochondria, which are about 30% composed of phospholipids and which carry out important metabolic processes, including oxidative phosphorylation. With a deficit of phospholipids is disturbed fat metabolism, which leads to fatty liver. Due to its pharmacological properties Essentiale eliminates these disturbances, regeneration of cell membranes, activates the broken membrane-bound enzyme systems and receptors, increases the ability of the liver detoxification, and thus normalizes its function.
The half-life for the choline component is 66 hours, for saturated fatty acids - 32 hours.
In studies on pharmacokinetics in humans of less than 5% of each of the introduced isotopes 3H and 14C were allocated in the faeces.
Fatty degeneration of the liver (as in diabetes), acute and chronic hepatitis, cirrhosis, necrosis of liver cells, hepatic coma and precoma, toxic liver damage, including toxaemia of pregnancy, pre-and postoperative treatment, particularly in operations in the area of hepatobiliary zone, psoriasis and neurodermatitis ; radiation syndrome.
How to use:
In the absence of any other doctor's recommendations, the initial dose: 2 capsules 3 times a day, maintenance dose: 1 capsule 3 times a day. Take the capsules during a meal, without chewing, drinking a little water.
Adults and children prescribed by slow intravenous 5-10 ml per day, and in severe cases - from 10 to 20 ml per day. For once allowed to enter up to 10 ml of the drug. If the drug is administered diluted, it is recommended to use the patient's own blood and dilute the drug in a 1:1 ratio.Intravenous injections are usually used within 10 days. Recommended as early as possible to maintain (add) parenteral therapy capsules Essentiale (Essentiale forte).
The total course of treatment is 3-6 months.
Treatment of psoriasis begins with the appointment of the drug to 2 capsules 3 times daily for 2 weeks, and then make 10 intravenous injections of 5 ml of the drug with the simultaneous appointment of PUVA-therapy.
After completing the course of injections resume taking the drug inside and keep it for 2 months.
Very rarely, higher doses may Essentiale gastrointestinal upset (diarrhea).
You should not use the drug in case of hypersensitivity to any component.
Solution for intravenous injection should not be administered to premature infants and children as a part of this release form of the drug is benzyl alcohol.
Can be used during pregnancy and lactation, but only on the advice of a doctor!
Interaction with other drugs:
For dilution solution for intravenous injection should not be used electrolyte solutions.
Reports of overdose have been reported.
Forte 300 mg capsules of 30 or 100 pieces per package.
Ampoules of 5 ml to 5 pieces per pack.
Shelf life 3 years. Capsules stored at temperatures not above 25 ° C, and vials at a temperature of +2 ° C to 8 ° C, dry, place inaccessible to children.
Conditions of supply of pharmacies - prescription.
Essentiale Forte (Essentiale Forte), Essentiale Forte N (Essentiale Forte N), Essentiale N (Essentiale N)
1 capsule Essentiale (Essentiale forte) provides:
Active ingredient: "essential phospholipids" = EFL-Essence (diglitseridnye holinfosfornoy acid esters of natural origin with a high content of unsaturated fatty acids, mainly linoleic (70%), linolenic and oleic acids) - 300 mg.
Other ingredients: hard fat, refined soybean oil, hydrogenated castor oil, ethanol, etilvanilin, 4-metoksiatsetofenon, dyes, E171, E172, DL-a-tocopherol.
1 ampoule of 5 ml Essentiale (Essentiale N) contains:
Active ingredient: "essential phospholipids" = EFL-Essence (diglitseridnye holinfosfornoy acid esters of natural origin with a high content of unsaturated fatty acids, mainly linoleic (70%), linolenic and oleic acids) - 250 mg.
Other ingredients: benzyl alcohol, dizoksiholevaya acid, sodium chloride, sodium hydroxide, dye - riboflavin, water for injection.
At a dilution of the solution Essentiale (Essentiale N) for solution for injection (in case you can not use the patient's own blood) should be applied solutions, free of electrolytes, as follows: 5% or 10% glucose solution (1:1) , 5% solution of xylitol.
It is not permissible to enter a drug intramuscularly, as you may experience local irritation.
A. Nattermann & Cie. GmbH (Germany).
Before using the drug Essentiale you should consult your doctor. This manual is intended solely for information.