AGAPURIN tablets 100mg
Instructions Agapurin pills of 100 mg
Composition Agapurin pills of 100 mg and the form of
etc. 100 mg, № 60
Active substance: Pentoxifylline - 100 mg
Other ingredients: lactose monohydrate, maize starch, talc, magnesium stearate, colloidal anhydrous silica, sodium carmellose, sucrose, powdered sugar, acacia, titanium dioxide (E171).
Pharmacodynamics. Due to inhibition of the enzyme PDE relaxes the smooth muscles of the arterioles, and then there is an accumulation of cAMP. Pentoxifylline reduces blood viscosity, mainly in the capillaries. As a result - improve the circulation of blood and oxygen supply. It inhibits the adhesion and aggregation of platelets. Pentoxifylline increases the flexibility and elasticity of red blood cells, increasing the concentration of ATP in the environment. Pentoxifylline has anti-inflammatory and cytoprotective effects, which is based on the reduction of macrophage cytokine synthesis and reducing neutrophil activation. These properties can be used in the treatment of asthma, sepsis and endotoxin shock.
Pharmacokinetics. When taken orally, pentoxifylline is rapidly and almost completely (over 95%) is absorbed in the gastrointestinal tract. Due to the high first-pass effect of its bioavailability is approximately 25-45%. The maximum level is reached within 30 minutes with a value of about 1.1 mg / ml (after administration of 200 mg orally). T ½ is approximately 1 hour Pentoxifylline is extensively metabolized in the liver and red blood cells. Metabolite I (restored 5-hydroxy) very quickly appears in the blood and reaches a level equal to the level of pentoxifylline but appears slower. Metabolite V (Z'-karboksipropilproizvodnaya) appears in the blood later and reaches almost 2 times higher than the level of the active substance and excreted more slowly (biological T ½ is about 2 h), the largest portion of metabolites in the urine. About 94 and 4% of pentoxifylline appear in the form of metabolites in the urine and feces, respectively. Approximately 1-2% of the applied dose is excreted as unchanged pentoxifylline. Up to 90% of the dose is eliminated for 4 hours after application.
Indications for use Agapurin tablets of 100 mg
chronic peripheral arterial circulatory disorders and arteriovenous by atherosclerosis, diabetes, degenerative disorders and angioneyropatii;
acute and chronic retinal and choroidal vascular insufficiency;
circulatory disorders of the inner ear.
Application Agapurin tablets of 100 mg
used in adults. The initial dose is 200 mg pentoxifylline three times a day for 1 week of treatment. In the event of hypotension, negative reactions from the gastrointestinal tract or the CNS initial dose may be reduced to 100 mg pentoxifylline three times daily. Prolonged treatment take 100 mg pentoxifylline three times daily. The maximum daily dose - 1200 mg.
Dragee be taken without chewing, drinking plenty of water during or after a meal, preferably in the same time. The length of treatment depends on the type and course of the disease is determined by the doctor individually.
Hypersensitivity to pentoxifylline and other components of the drug or other drugs in the group of methylxanthines;
bleeding in the retina;
bleeding in the brain;
acute phase of myocardial infarction;
Pregnancy and breast-feeding;
children's age (18 years).
Cardio-vascular system: tachycardia, rapid heart rate, arrhythmia, angina, flushing, hypotension, hemorrhage (eg in the skin, mucous membranes, stomach, intestines), and thrombocytopenia.
CNS: anxiety, insomnia, hallucinations, dizziness, headache.
Gastrointestinal: nausea, vomiting, flatulence, abdominal pain, diarrhea.
On the part of blood formation: aplastic anemia, and thrombocytopenia.
From a metabolism: hypoglycemia, cholestasis.
On the part of the respiratory system: bronchospasm.
From the senses: blurred vision.
Of the skin: allergic skin reactions, erythema, pruritus, urticaria, angioedema, increased sweating.
Others: anaphylactic shock, elevated liver enzymes.
Cautions when using Agapurin pills of 100 mg
for patients with labile or decrease blood pressure, or a significant decrease in renal function (creatinine clearance <30 mL / min), for patients at special risk with respect to the effects of reduced blood pressure (such as severe coronary vessels, significant stenosis of major vessels of the brain) to start treatment with a low dose, individually select doses and increase them gradually with the tolerability of treatment.
Care should be taken with a drug to patients with severe cerebral atherosclerosis and coronary artery disease, particularly with concomitant hypertension and cardiac arrhythmias. In such patients, the drug can angina, arrhythmias, and hypertension. It should also be used with caution to patients with gastric and duodenal ulcers in history, those who have recently had surgery (increased risk of bleeding, and therefore requires systematic monitoring of hemoglobin and hematocrit). Myocardial infarction requires particular care to think about the indication for treatment with pentoxifylline, given all the possible side effects that can occur when using the drug.
If necessary, use in patients with chronic heart failure should reach pre-compensation phase circulation.
If the kidney function with serum creatinine> 400 mmol / l (or creatinine clearance <10 mL / min), the dose selected individually, reducing it by about 50-70%. In severe liver failure is also necessary to reduce the dosage based on individual tolerability.
The drug contains lactose, therefore patients with rare hereditary form of galactose intolerance, lactase deficiency or glucose-galactose syndrome malabsorption should not use the drug Agapurin.
The product contains sucrose, which should be considered when appointing his diabetes.
Use during pregnancy and lactation. Agapurin contraindicated in pregnancy. If necessary, use in women who are breastfeeding, the period of treatment should stop breastfeeding.
Children. The drug is not indicated for the treatment of children and adolescents under the age of 18.
Influence on ability to drive a vehicle or operate other machinery. Given that sensitive patients when using the drug may have side effects (dizziness, blurred vision, etc.) while taking the drug should refrain from driving and other work requiring concentration.
Interaction Agapurin pills 100 mg with other drugs
Pentoxifylline enhances the effect of antihypertensive and other vasodilating substances that may cause severe hypotension. While the application of adrenergic agents and ganglionic may experience a significant decrease in blood pressure. The simultaneous use of adrenergic agents or xanthine leads to excitation of the central nervous system. Higher doses of pentoxifylline potentiate the effect of insulin and oral hypoglycemic agents. Due to the risk of hypoglycemia is recommended more often to measure the level of glucose in the blood, and eventually carry out the correction of antidiabetic therapy. Pentoxifylline increases the frequency of bleeding complications in patients who were simultaneously treated with anticoagulants, antiplatelet and thrombolytic agents. Patients who simultaneously used anticoagulants, should be increased to measure the prothrombin time. Cimetidine increases the concentration of pentoxifylline in the blood plasma, thereby increasing the risk of adverse reactions to it.
In diabetic patients receiving treatment with insulin or oral antidiabetic agents, the use of the drug in high doses may increase the effects of these drugs on blood sugar levels. In these cases it is necessary to reduce the dose of insulin or oral antidiabetic agents and carefully monitor the patient's health.
Symptoms: The initial symptoms of acute overdose of pentoxifylline may include nausea, dizziness, tachycardia, or a decrease in blood pressure. In the future, possible fever, fever, agitation, hot flushes, loss of consciousness, areflexia, tonic-clonic seizures, and vomiting "coffee grounds" as a sign of gastrointestinal bleeding.
Treatment: In case of overdose should stop further systemic absorption of pentoxifylline by first removing (eg gastric lavage), or delay its absorption (eg activated carbon). The specific antidote is unknown. Treatment of acute overdosage is symptomatic.
in a dry place at a temperature not exceeding 25 ° C.
Instructions on the drug Agapurin pills 100 mg provided for informational purposes only with the drug and not a guide to self-medication. Before using the product Agapurin tablets 100 mg, consult a physician profiling. Also, you can get advice from our pharmacists about the availability, method of application, the selection of analogs of the drug, the possibility of his book, the timing of delivery. Delivery Agapurin tablets 100 mg is a courier service on behalf of clients. Otherwise, you can pick up the medication from the pharmacy itself.