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Metrogyl Denta gel 20gr

Metrogyl Denta gel 20gr

Brand: India
Product Code: 198
Availability: In Stock
Price: $4.80
Qty:     - OR -  
DELIVERY WITHIN 9-11 DAYS.
Metrogyl gel for external using (10 mg/g , 30g tube)
 
Manufacturer: Unique Pharmaceutical Laboratories, India
 
International name: Metronidazole
 
ATC code: D06BX01
 
Pharmacotherapeutic group
 
Chemotherapeutic agents for local use. The sulfonamides.
 
Composition
 
active substance: metronidazole;
 
1 g of gel contains metronidazole 10 mg;
 
other ingredients: parahydroxybenzoate (E 216), propylene glycol, carbomer 940, disodium edetate, sodium hydroxide, methyl parahydroxybenzoate (E 218), purified water.
 
Dosage form: Gel for external use.
 
Main physico-chemical properties: homogeneous gel from colorless to yellow.
 
Pharmacotherapeutic group
 
Chemotherapeutic agents for local use. Code ATC D06B X01.
 
Pharmacological properties
 
Pharmacodynamics.
 
Metronidazole derivative of 5-nitroimidazole, is active against anaerobic protozoa and anaerobic bacteria. Metronidazole is effective against Trichomonas vaginalis, Giardia intestinalis, Gardnerella vaginalis, Entamoeba histolytica, Lamblia spp., as well as obligate anaerobes: Bacteroides spp. (B. fragilis, B. distasonis, B. thetaiotaomicron, B. vulgatus, B. ovatus), Fusobacterium spp. and some gram-positive microorganisms: Eubacterium spp. Clostridium spp. Peptostreptococcus spp., Peptococcus spp.
 
Metronidazole for external use has a slight antioxidant activity.
 
Found that metronidazole significantly decreases the production of neutrophils active oxygen, hydroxyl radicals and hydrogen peroxide that are potential oxidants and can damage tissue at the site of inflammation.
 
The mechanism of action of metronidazole consists in biochemical restoration of 5-nitro group of metronidazole intracellular transport proteins anaerobic microorganisms and protozoa. Restored 5-ntergraph of metronidazole interacts with DNA of microorganisms, inhibiting its synthesis, leading to death of microorganisms.
 
The local application of the drug is effective against acne, but the mechanism of action is not fully understood.
 
Pharmacokinetics.
 
When applied topically, the drug absorption is minimal and only a small amount of the drug found in blood plasma. Absorbed metronidazole crosses the placental and blood-brain barriers. The maximum concentration in the blood reaches 66 mg/ml (when applied in 1 g gel, equivalent to 7.5 mg of metronidazole).
 
Indications: For topical application in the treatment of inflammatory papules, pustules and erythema in rosacea.
 
Contraindications: Hypersensitivity to metronidazole, nitroimidazole derivative and any components included in the preparation.
 
Interaction with other medicinal products and other forms of interaction
 
When applied topically in recommended doses, systemic interaction of Metrogyl gel® with other drugs have not been identified. However, one should be careful when assigning gel Metrogyl ® with certain medicines.
 
Warfarin and other anticoagulants cumarin. Metronidazole enhances the anticoagulant effect, which leads to a lengthening of the time of formation of prothrombin.
 
Phenobarbital. While the use of metronidazole reduced antimicrobial activity of the latter. The reason – presvedceni the metabolism of metronidazole.
 
Disulfiram. Simultaneous application enhances the toxicity of drugs that may lead to the development of neurological symptoms.
 
Cimetidine. Inhibits the metabolism of metronidazole, which may cause increased concentration of metronidazole in serum.
 
With systemic therapy matrangas should refrain from drinking alcohol as possible disulfiramopodobna reaction.
 
Application features
 
To avoid preparation hit in eyes. If the gel gets into your eyes, you must immediately rinse with plenty of water.
 
Do not apply gel to areas located close to the eyes. The affected area should be cleaned before applying the gel Metrogyl®. After applying the product you can use cosmetics.
 
When conventional acne gel Metrogyl® should be combined with the intake of antibiotics.
 
When applied to a large surface area of the skin or in the case of long-term use of Metrogyl gel® there is a likelihood of systemic side effects.
 
The drug should be cautiously prescribed to patients with dysfunction of the hemopoietic system.
 
Metronidazole for external use are not effective for treatment of telangiectasia, which occurs when red acne.
 
Parahydroxybenzoate (E 216) and methyl parahydroxybenzoate (E 218), members of the drug may cause allergic reactions (possibly delayed).
 
Use during pregnancy or breast-feeding.
 
Despite the fact that in the case of local application the concentration of metronidazole in the blood is low, Metrogyl® gel is contraindicated in the first trimester of pregnancy, in II and III trimestrah it can be used in cases of extreme need. For the period of treatment should stop breast-feeding.
 
The ability to influence the reaction rate when driving motor transport or operating other mechanisms: The use of the drug in the specified dose not affect driving or working with potentially dangerous machinery.
 
Method of application and doses
 
For external use only!
 
Gel apply a thin layer to the affected area of the skin after cleaning. Apply twice a day (morning and evening).
 
The duration of treatment determined by the physician individually. If necessary, apply occlusion bandage. Therapeutic effect is observed after 3 weeks of treatment.
 
Children: Do not apply to children.
 
Overdose: Overdoses of gel Metrogyl® are unknown. The local application, metronidazole is absorbed in small quantities.
 
Adverse reactions:
 
It was reported the following side effects: lacrimation (if the gel close to the eyes), temporary reddening of the skin (erythema), skin rash, light dryness, itching, burning, local increase in skin temperature and skin irritation.
 
Side effects occurred no more than 2% of patients.
 
Parahydroxybenzoate (E 216) and methyl parahydroxybenzoate (E 218), members of the drug may cause allergic reactions (possibly delayed).
 
Shelf life: 3 years.
 
Storage conditions: Keep at temperature not exceeding 25 °C. do Not freeze. Store in a place inaccessible to children.
 
Packaging: 30 g in a tube of aluminum or laminated plastic. 1 tube in a cardboard box.
 
Manufacturer: "Peronda" (company branch "George. Kemkes & pharmaceuticals Ltd.")
 
Location of manufacturer and address of place of business
 
Plot No. 304-308, G. Ay. Di. Si. Industrial Era, city Panel – 394 116, Bharuch district, India.

 

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