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Crestor tablets 10 mg #28 - Cardiovascular

Crestor tablets 10 mg #28 - Cardiovascular

Brand: United Kingdom
Product Code: 047
Availability: In Stock
Price: $79.00
Qty:     - OR -  


Crestor Description

Crestor is the market name for the medicine Rosuvastatin. The drug Crestor was originally developed by the Japanese firm Shionogi. It is marketed by AstraZeneca which holds the patent for this drug until 2016. The drug has been available in the US market since August 2003 when it was approved by the Food and Drug Authority (FDA). From 2004 onwards it has reached 154 countries and likely to reach in further 50 odd countries. Crestor belongs the category of drugs called Statins. These are responsible for lowering LDL cholesterol by 1.8 mmol/l (70 mg/dl). In practical terms this means that there is a 60% lesser chance of heart attack and a 17% lower risk of stroke.

Conditions Treated by Crestor

Crestor or Rosuvastatin helps to maintain a healthy level of cholesterol. It does this by lowering the level of LDL or low-density lipoprotein cholesterol and boosts the level of HDL cholesterol(high-density). In order to be most effective however, Crestor needs to be accompanied by a healthy diet with adequate exercise. This combination works best to reduce overall elevated levels of cholesterol LDL cholesterol, ApoB, non-HDL cholesterol and triglycerides in adult patients who suffer from hyperlipidemia and mixed dyslipidemia. Crestor is also prescribed as a preventive medicine to slow the progression of atherosclerosis in patients at risk.

Crestor Dosage Information

a.) Typical Dosage Recommendations

Crestor tackles a critical area that is cholesterol hence the medicine must be taken exactly as prescribed. The dosage for Crestor is carefully determined on individual conditions of the patient, which is also why the medicine should never be shared. Crestor is usually recommended for consumption once daily. The tablet comes in variable doses ranging from 5 to 40 mg. On an average the dose on starting Crestor is 10-20 mg. The medicine does not necessarily have to be taken with food, but it is better to take it at a similar time everyday. It is best to take Crestor with a glass of water.

b.) Missing A Dose

Missing a dose for a medicine is quite likely especially in the initial stages when you have just started taking the medicine; this holds true for Crestor also. The medicine needs to be taken once daily so if you forget it and it has been less than 12 hours then you can take the missed dose. But if it is more than 12 hours then you can wait and take the next dose of Crestor. Always maintain the dose that has been recommended rather than increasing or decreasing it for any reason.

c.) Overdosing

Every medicine can have different results on different people. An overdose is also quite likely but the effect can differ across people depending on individual factors. There is not enough evidence about the effect of overdose of Crestor. However it is well known that an overdose increases the likelihood of side effects. Hence if there is a suspected overdose of Crestor, it is best to take immediate medical help, rather than try to manage it on your own. The doctor might try to pump out the medicine if it is a recent event. This would be accompanied by a close monitoring of the blood pressure and heartbeat.

Crestor Warnings

Crestor is a medicine that should be taken with a prescription only. There should be no modifications in this without consulting a doctor. While Crestor is generally recommended for both adults and children, it needs to be prescribed with caution in patients above 65 years of age. For pediatric cases, the dosage might be varied according to each patient and the severity of his or her condition. Crestor is not advisable for women who are trying to have a baby, those who are pregnant or those who are breast-feeding mothers. Patients with a past history of liver problems or problems in the functioning of kidneys should be given Crestor with caution. Some additional tests might also be required for such patients to ensure the efficacy and safety of the drug. As stated previous sections, Crestor works effectively only with it is accompanied by healthy lifestyle changes such as a nutritious low fat diet, moderate exercise and no alcohol. Alcohol should be completed avoided by patients who are on Crestor as it is known to damage the liver and increase the triglyceride levels. Patients should also avoid taking any antacids on their own when they are taking Crestor as this might make the absorption of Crestor more difficult. If an antacid is needed, it is best to get a prescription from your doctor who knows that you are on Crestor.

Crestor Side Effects

A side effect is not a great cause for worry as most drugs have some form of side effect or the other. Likewise Crestor also has some side effects. There are techniques to manage these side effects therefore the patient must report the side effects to their doctor immediately. But patients must never make any dosage or other alterations in Crestor without consulting their doctor. Some of the mild side effects of Crestor are:

  • Nausea
  • Headaches or dizziness
  • Sore throat or cold like symptoms
  • Memory related problems
  • Weakness
  • Pain or burning sensation while urinating

There are also more severe side effects of Crestor:

  • Edema on hands and feet
  • Muscle pain or tenderness
  • Flu like symptoms
  • Jaundice
  • Nausea and stomach pain
  • Chest pain
  • Urination disorders

Possible Drug Interactions With Crestor

The chemical compounds in two drugs that are taken simultaneously interact to produce different reactions. Furthermore the nature of these reactions could differ across individuals depending on their specific conditions. Even herbal medicines and non-allopathic medicines can interact with allopathic drugs. Hence patients who are about to start taking Crestor must inform their doctor about all the medicines that they are taking at the time. Following are the drugs that are known to interact with Crestor. However this list is not an exhaustive one.

  • Tricor (fenofibrate)
  • Coumadin(warfarin)
  • Nizoral (ketoconazole)
  • Norvir (ritonavir)
  • Tagamet (cimetidine)
  • Neoral (cyclosporine)
  • Niacin
  • Aldactone (spironolactone)




CRESTOR is an HMG Co-A reductase inhibitor indicated for:

  • patients with primary hyperlipidemia and mixed dyslipidemia as an adjunct to diet to reduce elevated total-C, LDL-C, ApoB, nonHDL-C, and TG levels and to increase HDL-C (1.1)

  • patients with hypertriglyceridemia as an adjunct to diet (1.2)

  • patients with primary dysbetalipoproteinemia (Type III hyperlipoproteinemia) as an adjunct to diet (1.3)

  • patients with homozygous familial hypercholesterolemia (HoFH) to reduce LDL-C, total-C, and ApoB (1.4)

  • slowing the progression of atherosclerosis as part of a treatment strategy to lower total-C and LDL-C as an adjunct to diet (1.5)

Limitations of use (1.6):

  • Effect of CRESTOR on cardiovascular morbidity and mortality has not been determined.

  • CRESTOR has not been studied in Fredrickson Type I and V dyslipidemias.



  • CRESTOR can be taken with or without food, at any time of day. (2.1)

  • Dose range: 5-40 mg once daily. Use 40 mg dose only for patients not reaching LDL-C goal with 20 mg. (2.1)

  • Hyperlipidemia, mixed dyslipidemia, hypertriglyceridemia, primary dysbetalipoproteinemia, and atherosclerosis: Starting dose 10 mg. Consider 20 mg starting dose for patients with LDL-C>190 mg/dL and aggressive lipid targets. (2.2)

  • HoFH: Starting dose 20 mg. (2.3)




Tablets: 5 mg, 10 mg, 20 mg, and 40 mg (3)



  • Known hypersensitivity to product components (4)

  • Active liver disease, which may include unexplained persistent elevations in hepatic transaminase levels (4)

  • Women who are pregnant or may become pregnant (4, 8.1)

  • Nursing mothers (4, 8.3)



  • Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase with use of 40 mg dose, advanced age (>65), hypothyroidism, renal impairment, and combination use with cyclosporine, lopinavir/ritonavir, or certain other lipid-lowering drugs. Advise patients to promptly report unexplained muscle pain, tenderness, or weakness and discontinue CRESTOR if signs or symptoms appear (5.1)

    Liver enzyme abnormalities and monitoring: Persistent elevations in hepatic transaminases can occur. Monitor liver enzymes before and during treatment. (5.2)




Most frequent adverse reactions (rate > 2%) are headache, myalgia, abdominal pain, asthenia, and nausea. (6.1)

To report SUSPECTED ADVERSE REACTIONS, contact AstraZeneca at 1-800-236-9933 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch



  • Cyclosporine: Combination increases rosuvastatin exposure. Limit CRESTOR dose to 5 mg once daily. (2.5, 7.1)

  • Gemfibrozil: Combination should be avoided. If used together, limit CRESTOR dose to 10 mg once daily. (2.6, 5.1, 7.2)

  • Lopinavir/Ritonavir: Combination increases rosuvastatin exposure. Limit CRESTOR dose to 10 mg once daily. (2.5, 5.1, 7.3)

  • Coumarin anti-coagulants: Combination prolongs INR. Achieve stable INR prior to starting CRESTOR. Monitor INR frequently until stable upon initiation or alteration of CRESTOR therapy. (5.3, 7.4)

  • Concomitant lipid-lowering therapies: Use with fibrates and niacin products may increase the risk of skeletal muscle effects. (2.6, 5.1, 7.5, 7.6)



  • Pediatric use: Safety and effectiveness not established. (8.4)

  • Severe renal impairment (not on hemodialysis): Starting dose is 5 mg, not to exceed 10 mg. (2.7, 5.1, 8.6)

  • Asian population: Consider 5 mg starting dose. (2.4, 8.8)



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