Information about the drug, Axetin given in this section is intended for medical and pharmaceutical professionals and should not be used for self-treatment. Information given to familiarize with the basic properties of the drug and cannot be considered as official.
active substance: 1 vial contains 0.750 in g or 1.5 g of cefuroxime sodium equivalent to cefuroxime.
Medicinal form. Powder for preparation of solution for injection.
Pharmacotherapeutic group. Antimicrobial agents for systemic use. Cephalosporins second-generation. Cefuroxime.
ATC code J01D C02.
Testimony. Infectious-inflammatory diseases caused by susceptible to cefuroxime by micro-organisms.
Respiratory tract infections: acute and chronic bronchitis, infected bronchiectasis, bacterial pneumonia, pneumonia, post operative infections of the chest cavity.
Infections of ENT organs: sinusitis, tonsillitis, pharyngitis and otitis media.
Urinary tract infections: acute and chronic pyelonephritis, cystitis, bacteriuria and symptomatic.
Soft tissue infections, including erysipelas and wound infections.
Infections of bones and joints: osteomyelitis, septic arthritis.
Gonorrhea, especially in those cases when penicillin is contraindicated.
Other infections, including septicemia, meningitis, peritonitis.
Prevention of infections at increased risk of development of infectious complications on thoracic cage and abdominal cavity, operations on pelvic organs, cardiovascular and orthopedic operations.
If necessary, the drug can be used in combination with amino glycoside antibiotics or with metronidazole (orally, in suppository or injection), especially for prophylaxis of infections in abdominal and gynecologic operations.
Contraindications. Hypersensitivity to cephalosporin antibiotics.
Method of application and doses. Administered intramuscularly and inside venous (bolus and drip). The dose depends on the sensitivity of micro-organisms, severity of infection, age, body mass and condition of renal function.
Rules for preparation of solution for parenteral administration.
For intramuscular injection should add 3 ml water for injection to 0,750 g of Axetine. Shake gently to the appearance of an opaque suspension. Slurry can be stored in the refrigerator for 24 hours, however, it is recommended to use freshly prepared solution.
For intravenously introducing dissolving 0,750 g of Axetine in 6 ml of water for injection, 1.5 g of Axetine in 15 ml of water for injection. For infusions lasting no more than 30 minutes, 1.5 g of cefuroxime was dissolved in 50 ml of solvent (0.9% sodium chloride solution, ringer solution). During storage of dilute solutions may be changes in color saturation.
For many infections enough the introduction of 0,750 g 3 times per day intramuscular× Azovo or internally tively. In more severe conditions the dose can be increased to 1.5 g 3 times a day orally tively. If necessary, the interval between administrations may be shortened to 6 hours, total daily dose 3-6 g.
Infants and children:
0,03-0,1 g/kg per day in the form of 3-4 injections. For most infections, the optimal dose is 0.06 g/kg per day.
0,03-0,1 g/kg per day in 2-3 injections. Be aware that the half of the excretion of cefuroxime in the first weeks of life can be 3-5 times more than adults.
Elderly patients: dosage as for adults.
The impairment of renal function.
Cefuroxime is excreted by the kidneys. Therefore, as the use of other similar antibiotics, patients with compromised kidney function are advised to reduce the dose to Axetine to compensate for the slower excretion of the drug. There is no need to reduce the standard dose (0,750-1.5 g 3 times daily) until the creatinine clearance level will not be 20 ml/min or lower. Adults with severe impaired renal function (creatinine clearance 10-20 ml/min) recommended dose 0,750 g 2 times a day, in more severe cases (creatinine clearance less than 10 ml/min) – 0,750 g of 1 times a day.
With hemodialysis, you need to enter 0,750 g orally-venous or intramuscular× Azovo at the end of each dialysis session. In addition to the introduction of parenteral cefuroxime can be added to peritoneal dialysis fluid (typically 0.25 g for every 2 litres of dialysis fluid). For patients undergoing long-term hemodialysis or a quick hemofiltration in the intensive care units, the recommended dose is 0,750 g twice a day. Patients who received hemofiltration slow, you need to follow the dosing scheme for the treatment with impaired renal function.
Adverse reactions. When applying Oxetine side effects occurred less frequently, was moderately expressed and wore.
The frequency of adverse reactions, given below, was determined as: very common (= > 10%), common (= > 1 % - < 10 %), uncirculated (= > 0,1 % - < 1 %), rarely common (= > 0.01% - < 0.1%), common very rare (< 0.01%).