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Axetin (Cefuroxime) Powder for solution 1.5g 10 bottles

Axetin (Cefuroxime) Powder for solution 1.5g 10 bottles

Brand: Medochemie
Product Code: 142
Availability: In Stock
Price: $70.90
Qty:     - OR -  
DELIVERY WITHIN 9-11 DAYS.
Information about the drug, Axetin given in this section is intended for medical and pharmaceutical professionals and should not be used for self-treatment. Information given to familiarize with the basic properties of the drug and cannot be considered as official.
 
Composition:

active substance: 1 vial contains 0.750 in g or 1.5 g of cefuroxime sodium equivalent to cefuroxime.

Medicinal form. Powder for preparation of solution for injection.

Pharmacotherapeutic group. Antimicrobial agents for systemic use. Cephalosporins second-generation. Cefuroxime.

ATC code J01D C02.

Clinical features.

Testimony. Infectious-inflammatory diseases caused by susceptible to cefuroxime by micro-organisms.

Respiratory tract infections: acute and chronic bronchitis, infected bronchiectasis, bacterial pneumonia, pneumonia, post operative infections of the chest cavity.

Infections of ENT organs: sinusitis, tonsillitis, pharyngitis and otitis media.

Urinary tract infections: acute and chronic pyelonephritis, cystitis, bacteriuria and symptomatic.

Soft tissue infections, including erysipelas and wound infections.

Infections of bones and joints: osteomyelitis, septic arthritis.

Gonorrhea, especially in those cases when penicillin is contraindicated.

Other infections, including septicemia, meningitis, peritonitis.

Prevention of infections at increased risk of development of infectious complications on thoracic cage and abdominal cavity, operations on pelvic organs, cardiovascular and orthopedic operations.

If necessary, the drug can be used in combination with amino glycoside antibiotics or with metronidazole (orally, in suppository or injection), especially for prophylaxis of infections in abdominal and gynecologic operations.

Contraindications. Hypersensitivity to cephalosporin antibiotics.

Method of application and doses. Administered intramuscularly and inside venous (bolus and drip). The dose depends on the sensitivity of micro-organisms, severity of infection, age, body mass and condition of renal function.

Rules for preparation of solution for parenteral administration.

For intramuscular injection should add 3 ml water for injection to 0,750 g of Axetine. Shake gently to the appearance of an opaque suspension. Slurry can be stored in the refrigerator for 24 hours, however, it is recommended to use freshly prepared solution.

For intravenously introducing dissolving 0,750 g of Axetine in 6 ml of water for injection, 1.5 g of Axetine in 15 ml of water for injection. For infusions lasting no more than 30 minutes, 1.5 g of cefuroxime was dissolved in 50 ml of solvent (0.9% sodium chloride solution, ringer solution). During storage of dilute solutions may be changes in color saturation.

Adults:

For many infections enough the introduction of 0,750 g 3 times per day intramuscular× Azovo or internally tively. In more severe conditions the dose can be increased to 1.5 g 3 times a day orally tively. If necessary, the interval between administrations may be shortened to 6 hours, total daily dose 3-6 g.

Infants and children:

0,03-0,1 g/kg per day in the form of 3-4 injections. For most infections, the optimal dose is 0.06 g/kg per day.

Newborns:

0,03-0,1 g/kg per day in 2-3 injections. Be aware that the half of the excretion of cefuroxime in the first weeks of life can be 3-5 times more than adults.

Elderly patients: dosage as for adults.
 
The impairment of renal function.

Cefuroxime is excreted by the kidneys. Therefore, as the use of other similar antibiotics, patients with compromised kidney function are advised to reduce the dose to Axetine to compensate for the slower excretion of the drug. There is no need to reduce the standard dose (0,750-1.5 g 3 times daily) until the creatinine clearance level will not be 20 ml/min or lower. Adults with severe impaired renal function (creatinine clearance 10-20 ml/min) recommended dose 0,750 g 2 times a day, in more severe cases (creatinine clearance less than 10 ml/min) – 0,750 g of 1 times a day.

With hemodialysis, you need to enter 0,750 g orally-venous or intramuscular× Azovo at the end of each dialysis session. In addition to the introduction of parenteral cefuroxime can be added to peritoneal dialysis fluid (typically 0.25 g for every 2 litres of dialysis fluid). For patients undergoing long-term hemodialysis or a quick hemofiltration in the intensive care units, the recommended dose is 0,750 g twice a day. Patients who received hemofiltration slow, you need to follow the dosing scheme for the treatment with impaired renal function.

Adverse reactions. When applying Oxetine side effects occurred less frequently, was moderately expressed and wore.

The frequency of adverse reactions, given below, was determined as: very common (= > 10%), common (= > 1 % - < 10 %), uncirculated (= > 0,1 % - < 1 %), rarely common (= > 0.01% - < 0.1%), common very rare (< 0.01%).
 
Overdose. Overdose cephalosporin antibiotics may lead to the development of symptoms of irritation of the brain, which could cause seizures. Levels of cefuroxime can be reduced by hemodialysis or peritoneal dialysis.

Usage during pregnancy or breastfeeding.

During pregnancy and lactation, Akcetin designated on the basis of the ratio of benefits to women and the potential risk for fetus (child).

Cefuroxime is excreted in breast milk.

Children.

The drug is used in children from the neonatal period.

Features of the application. With caution the drug is prescribed to patients who have had allergic reactions (anaphylactic reaction) to penicillins or other beta-lactam antibiotics.

Cephalosporin antibiotics in high doses should be used with caution in patients receiving treatment with potent diuretics such as furosemide, or amino glycoside antibiotics, because cases were reported undesirable effects on kidney function when this combination of drugs. As with other meningitis treatment schemes, for some children who were treated with cefuroxime, there were cases of partial hearing loss.

As with the treatment of other antibiotics, through 18-36 h after injection of cefuroxime into the cerebrospinal fluid culture was Haemophilus influenzae. However, the clinical significance of this phenomenon is not known.

When applying Axetine sequential therapy time of transition to oral Axetine is determined by the severity of infection, clinical state of the patient and sensitivity of micro-organism. In the absence of clinical improvement within 72 hours should continue parenteral administration of the drug.

The ability to influence on reaction rate while managing transport a car or operating other mechanisms. Does not usually affect ability to drive motor transport or operating other mechanisms, but in the case of dizziness and drowsiness should refrain from such activities.

Interaction with other drugs. While the use of diuretics is a slowdown kanalzeva secreta, reduced renal clearance, increasing the concentration of cefuroxime in plasma, the increase in T 1/2.

While the use of aminoglycosides and diuretics increases the risk of nefrotoksicskih effects.

Tools that reduce the acidity of gastric juice, reduce the absorption of cefuroxime and of its bioavailability.

Basic physical and chemical properties: powder white, or almost white.

Incompatibility. Not compatible with solutions of aminoglycosides in the same syringe.

Shelf life: 2 years.

Storage conditions. Store in a dry, protected from light and inaccessible to children at temperature not above 25 °C. In case of emergency, the prepared solution or suspension is stored for 24 hours in the refrigerator at 2 to 8 °C.

Packing. 750 mg or 1.5 g of powder in vial No. 10

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