Theraflex Advance 60 capsules - (128 USD) - PayPal accepted
Theraflex Advance 60 capsules

Theraflex Advance 60 capsules

Brand: Bayer AG, Germany
Product Code: 429
Availability: In Stock
Price: $28.00
General characteristics:
main physicochemical properties: hard gelatin capsules consisting of a cap of blue and gray case, with printed inscription “Theraflex Advance”, containing white powder with slight shades;
1 capsule contains glucose is a mine of sulphate 250 mg, chondroitin sulfate 200 mg; ibuprofen 100 mg;
auxiliary substances: gelatin, microcrystalline cellulose, silicon dioxide, starch is first romanized, stearic acid, crospovidon, magnesium stearate, titanium dioxide, polyvinylpyrrolidone, corn starch, FD&C Blue No. 1 Lacquer.
Form of issue. Capsules.
Pharmacotherapeutic group. Combined anti-inflammatory (Antirheumatic) agent. ATC code M 01V.
The pharmacological properties. 
Chondroitin sulfate is a mucopolysaccharide of high molecular weight, is involved in building cartilage. Reduces the activity of enzymes that destroy the articular cartilage and stimulates the regeneration of the latter. In the early stages of the inflammatory process chondroitin sulfate reduces its activity and thus slows down the degeneration of cartilage. Helps reduce pain, improve joint function, reduces the need for nonsteroidal anti-inflammatory drugs in patients with osteoarthritis of the knee and hip joints.
Glucose mine sulfate has chondroprotective properties, reduces the deficit glukozamin in the body, it takes part in the biosynthesis of proteoglycans and hyaluronic acid. Having an affinity to cartilage tissue, glucose minutes, initiates the process of fixation of sulfur in the synthesis chondroitinase acid. Glucose mine sulfate selectively acts on the articular cartilage, is a specific substrate and a stimulator of the synthesis of hyaluronic acid and proteoglycans, inhibits the formation of su peroxide radicals and enzymes that cause damage to the cartilage (collagen basics and phospholipase), prevents the damaging effect of glucocorticoids on chondrocytes and impaired biosynthesis of glycosaminoglycans induced by nonsteroidal anti-inflammatory drugs.
Ibuprofen has antipyretic, analgesic, anti-inflammatory effect. The mechanism of action occurs through the selective blocking of cyclooxygenase (COX) of the 1-St and 2-nd type – the main enzyme metabolism of arachidonic acid, which leads to a decrease in the synthesis of prostaglandins (PG), reducing their concentration in the cerebrospinal fluid and to decrease the excitation center thermoregulation. Reduces morning stiffness, increases range of motion in the joints and spine.
Pharmacokinetics. Absorption: after a single oral dose of the drug in average therapeutic dose of the maximum concentration of chondroitin sulfate in the blood plasma is reached after 3-4 hours, in the synovial fluid – through 4-5 hours. Drug bioavailability is 13%. Excretion is mainly by the kidneys within 24 hours. 90% of the enteral glucose mine absorbed from the intestine. More than 25% of the dose passes from the blood plasma to the cartilage and synovial membranes of the joints. In the liver of the drug is metabolized to urea, carbon dioxide and water.
The bioavailability glucose the mine is 25% due to “first pass” through the liver. The largest concentration of glucose mine determined in liver, kidney and articular cartilage. About 30% of the dose long persistiruut in bone and muscle tissues. Write mainly with urine in an unmodified form, partly with faeces. T ½ - 68 hours.
Ibuprofen in oral administration is almost completely absorbed from the gastrointestinal tract. Simultaneous food intake slows the rate of absorption. Metabolized in the liver (90%). T ½ 2-3 hours. 80% of the dose excreted in the urine primarily as metabolites.
Indications for use. Treatment of the pain syndrome in the acute phase with primary and secondary osteoarthritis of the limb joints and intervertebral discs.
Method of application and doses. Adults, children over 12 years: 2 capsules 2-3 times a day, after meals. Capsules are taken orally, squeezed small amounts of water. The duration of intake should not exceed 20 days. Further, with elimination of pain syndrome treatment, you can continue the drug for the treatment of colds.
Side effects. With increased individual sensitivity to the ingredients of the drug are sometimes seen slight nausea, epigastric pain, flatulence, diarrhea, diarrhea, and in rare cases - allergic reactions. You may experience headaches, sleep disorders. All symptoms disappear after discontinuation of the drug.
Contraindications. Individual hypersensitivity to any component of the drug (allergic reaction). Erosivno-azwenne shock syndrome in acute phase, diseases of the optic nerve, impaired Kropotkina, expressed human liver and kidneys, chronic heart failure, asthma that occurs when taking acetyl salicylic acid, phenylketonuria. Children up to age 12 years. Pregnancy and lactation.
Overdose. For a drug terafleks advance is not described. In case of overdose you may experience abdominal pain, nausea, vomiting, dizziness, headache, drowsiness, noise in the ears. In severe poisoning – a violation of the liver and kidneys. In case of overdose it is recommended gastric lavage, administration of activated charcoal, hospitalization in the Toxicological Department. Stationary phase used infusion therapy, forced diuresis, symptomatic treatment.
Features of the application. Do not exceed the recommended dose and duration of intake. Clinical data on efficacy and safety of the drug in children under 12 years, pregnant women and during lactation are not available. In patients with concomitant liver disease or kidney disease early treatment is recommended to control liver function and kidney picture of peripheral blood. Not recommended consumption of alcohol during treatment with Cheap advans. The drug does not affect ability to operate vehicles.
Interaction with other medicinal products. While the use of teraflex advans enhances the absorption of tetracyclines from the gastrointestinal tract and reduces, in pencil and chloramphenicol. Reduces the effect of antihypertensive drugs (ACE inhibitors, beta-blockers), diuretics (furosemide, gpotato), increases the effects of anticoagulants. Concurrent use of nonsteroidal anti-inflammatory drugs or corticosteroids increases the risk of developing side effects from the gastrointestinal tract.
The conditions and duration of storage. Keep at temperature not exceeding 25 ° C in a dry, dark place inaccessible to children.
Shelf life – 2 years.
Packing. 60 or 120 capsules in a bottle; in a cardboard box.
Manufacturer. BAYER AG, Germany.

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