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Semax Nasal Spray 0,1% 3ml

Semax Nasal Spray 0,1% 3ml

Brand: Russia
Product Code: 440
Availability: In Stock
Price: $33.00
Qty:     - OR -  
DELIVERY WITHIN 9-11 DAYS.
SEMAX Nasal Spray 
 
Instruction
 
Composition:
 
active ingredient: semax (methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline);
 
1 ml of solution contains semax, in terms of 100% of the substance 1.0 mg;
 
Excipients: methyl parahydroxybenzoate (E 218), water purified.
 
Medicinal form
Drops of nasal 1%.
 
Pharmacotherapeutic group
Psychostimulants and nootropic drugs.
 
PBX code N06B X.
 
Indication
Intellectual-mnetic disorders with vascular lesions of the brain, conditions after craniocerebral trauma, neurosurgical operations and anesthesia, dyscirculatory encephalopathy, neurotic disorders of various genesis, including after ionizing radiation. To increase the adaptability of the human body in extreme situations, the prevention of mental fatigue under monotonous caretaker activities in the most stressful periods of labor in stressful conditions.
 
In ophthalmology: Semax® is used in atrophies of the optic nerve, neuritis of the inflammatory, toxic-allergic etiology.
 
In pediatrics: as a nootropic drug in children aged 5 years and older in the treatment of minimal cerebral dysfunctions (including attention deficit hyperactivity disorder syndrome).
 
Contraindication
Hypersensitivity to the components of the drug. Acute psychotic conditions, disorders that are accompanied by anxiety; history of convulsions, endocrine system diseases. Pregnancy and breastfeeding. Children up to 5 years old.
 
Method of administration and dose
Semax® is used intranasally, using a bottle enclosed with a plastic pipette cap.
 
1. Carefully cut the tip of the pipette in the specified location.
2. The cap should tightly close the pipette
3. Invert the bottle and, easily tapping your finger across the bottom, wait for the liquid to fill the entire space of the pipette.
4. Remove the cap and lightly press on the large part of the pipette to squeeze the required amount of drops of the drug into the nasal passage (on the mucous membrane)
 
Keep the drug with a tightly closed cap, as shown in Fig. 2
In one drop of standard solution contains 50 μg active ingredient. A pipette solution in the amount of no more than 2 to 3 drops is introduced in each nasal passage.
 
If necessary, an increase in the dosage of the injection is carried out in several receptions at intervals of 10 - 15 minutes.
 
The single dose is 200-2000 μg (at a rate of 3 - 30 μg / kg).
 
The daily dose is 500-5000 μg (from 7 to 70 μg / kg).
 
The drug is prescribed daily for 3 to 5 days, if necessary, the treatment is prolonged to 14 days.
 
For diseases of the optic nerve 2 - 3 drops in each nasal passage 2 - 3 times a day. The daily dose is 600 - 900 μg / day. The course of treatment - 7 - 10 days.
 
In addition, the drug can be administered by endonazal electrophoresis. The drug is introduced from the anode. Current strength 1 mA, duration of action 8 - 12 - 15 min.
 
The daily dose is 400 - 600 μg / day. The course of treatment is 7-10 days.
 
In pediatrics: with minimal cerebral dysfunction, the drug is dripped by 1 - 2 drops in each nasal passage 2 times a day (morning and evening). The daily dose is 200-400 mg / day. Course of treatment - 30 days.
 
Adverse reactions
Excitement, insomnia, with prolonged use, irritation of the nasal mucosa.
 
Overdose
The phenomenon of overdose with the drug so far could not be detected even with a significant increase in the single dose.
 
Use during pregnancy or breastfeeding
Not applicable.
 
Children
Do not use children under 5 years of age.
 
Application features
The drug should be applied to the mucous membrane of the nose, in-depth by inserting the pipette into the nasal passage.
 
Ability to influence the reaction speed when driving or working with other mechanisms
Does not affect
 
Interaction with other drugs and other types of interactions
Given the method of administering Semax® (intranasal), administration of intranasal agents that have a local vasoconstrictor effect is undesirable.
 
Pharmacological properties
Pharmacodynamics. Semax® nasal drops 0,1%, has an original mechanism of neurospecific action on the central nervous system. Semax®, nasal drops 0.1% is a synthetic analogue of corticotropin, possessing nootropic properties and completely deprived of hormonal activity.
 
The drug affects the processes associated with the formation of memory and training. Semax®, nasal drops of 0.1%, increases attention when training and analysis of information, improves the consolidation of the memorable trace; improves the adaptation of the body to hypoxia, cerebral ischemia, anesthesia and other damaging effects. The drug is practically non-toxic in one-time and long-term administration. Does not show allergic, embryotoxic, teratogenic and mutagenic properties. Does not act locally.
 
Pharmacokinetics. Absorbed from the mucous membrane of the nasal cavity, while digested up to 60-70% in conversion to the active substance. Semax® is rapidly distributed to all organs and tissues, penetrates through the blood-brain barrier. When injected into the blood, Semax® is exposed to very rapid degradation and excretion of the urine from the body.
 
Basic physical and chemical properties
transparent colorless liquid.
 
Incompatibility
Based on the chemical structure of the drug, the presence of chemically incompatible combinations is not expected: the drug rapidly collapses and does not enter the gastrointestinal tract.
 
Expiration date
2 years.
 
Storage conditions
Store in a place protected from light at a temperature not higher than 10 ° С, freezing is not allowed.
 
Keep out of the reach of children.
 
Packaging
3 ml in a glass vial, plugged in with a plastic cap-plug.
 

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